Oberste-Lehn H, Plempel M
Dermatologica. 1977;154(4):193-202.
The lack of experimental test models causes problems in comparative evaluation of photodynamic effects of 8-MOP and its possible derivatives after irradiation with blacklight or other irradiation sources. In our experiments in vitro, tests with various microorganisms and the in vivo model of experimental dermatophytosis in guinea pigs by Trichophyton mentagrophytes appeared to be suitable. In vivo, 8-MOP was applicated orally and topically in two formulations.
缺乏实验测试模型给比较评估8-甲氧基补骨脂素及其在黑光或其他辐射源照射后的可能衍生物的光动力效应带来了问题。在我们的体外实验中，对各种微生物进行的测试以及用须癣毛癣菌在豚鼠身上建立的实验性皮肤癣菌病体内模型似乎是合适的。在体内实验中，8-甲氧基补骨脂素以两种制剂形式口服和局部应用。
