Asch S, Knowles L, Rai A, Jones B E, Pogoda J, Barnes P F
Department of Medicine, University of Southern California School of Medicine, Los Angeles 90033, USA.
Am J Respir Crit Care Med. 1996 May;153(5):1708-10. doi: 10.1164/ajrccm.153.5.8630625.
To investigate the relationship between isoniazid resistance and HIV infection in patients with tuberculosis, we evaluated data in the Los Angeles County tuberculosis registry on 1,506 patients for whom drug susceptibility results were available. Among 235 HIV-infected patients, isoniazid resistance was less common than in 1,271 patients who were HIV-seronegative or who had not been tested for HIV, with an unadjusted odds ratio of 0.3. After adjustment for other factors that affect drug resistance (ethnicity, country of birth, prior diagnosis of tuberculosis, and cavitation), the frequency if isoniazid resistance remained lower than that in patients without HIV infection, with an odds ratio of 0.4 (95% confidence interval, 0.2 to 0.8; p = 0.02). We conclude that in Los Angeles, a setting where there is no ongoing outbreak of drug-resistant tuberculosis, isoniazid-resistant tuberculosis is not more common in HIV-infected patients.
为了研究结核病患者中异烟肼耐药性与HIV感染之间的关系，我们评估了洛杉矶县结核病登记处1506例有药敏结果患者的数据。在235例HIV感染患者中，异烟肼耐药情况比1271例HIV血清学阴性或未检测HIV的患者少见，未调整的比值比为0.3。在对影响耐药性的其他因素（种族、出生国家、既往结核病诊断和空洞形成）进行调整后，异烟肼耐药的频率仍低于未感染HIV的患者，比值比为0.4（95%置信区间为0.2至0.8；P=0.02）。我们得出结论，在洛杉矶这个没有正在发生的耐多药结核病疫情的地区，HIV感染患者中耐异烟肼结核病并不更常见。
