Sar Borann, Keo Chantary, Leng Chanthy, Saman Manil, Min Doung Chan, Chan Sarin, Monchy Didier, Sarthou Jean-Louis
Laboratory for Mycobacteriology, Unit of Clinical Testing, Institut Pasteur du Cambodge, Phnom Penh, Kingdom of Cambodia.
Southeast Asian J Trop Med Public Health. 2009 Jan;40(1):104-7.
The objective of this study was to observe the prevalence of drug resistance in Mycobacterium tuberculosis isolates in HIV associated tuberculosis co-infected patients in Phnom Penh City. The isolates of M. tuberculosis were collected during active laboratory-based surveillance. Of the 98 isolates studied, M. tuberculosis resistance to isoniazid was seen in 23.5%, resistance to rifampicin was seen in 16.3% and multidrug-resistance (MDR-TB) was seen in 5.1%. Our findings reveal an alarmingly high level of resistance to isoniazid and rifampicin, and confirms the need for drug susceptibility testing to guide treatment in patients with culture positive tuberculosis.
本研究的目的是观察金边市艾滋病毒合并肺结核患者中结核分枝杆菌分离株的耐药率。结核分枝杆菌分离株是在基于实验室的主动监测期间收集的。在所研究的98株分离株中，23.5%的结核分枝杆菌对异烟肼耐药，16.3%对利福平耐药，5.1%为耐多药（MDR-TB）。我们的研究结果显示对异烟肼和利福平的耐药水平高得惊人，并证实有必要进行药敏试验以指导痰培养阳性肺结核患者的治疗。
