氯离子/碳酸氢根离子交换体在大鼠空肠分离的肠上皮细胞中起作用。
Cl/HCO(-3) exchanger is operative in isolated enterocytes from rat jejunum.
作者信息
Tosco M, Orsenigo M N, Faelli A
机构信息
Dipartimento di Fisiologia e Biochimica Generali, Università di Milano, Italy.
出版信息
Experientia. 1996 Mar 15;52(3):245-8. doi: 10.1007/BF01920716.
Enterocytes isolated from rat jejunum were tested for the existence of a Cl-/HCO(-3) exchange, previously evidenced in basolateral membrane vesicles but not in brush border. Cells were found to retain functional integrity and transport capabilities long enough to allow Cl- fluxes to be measured. Both efflux and uptake experiments indicate that a Cl-/HCO(-3) antiport, inhibited by 4,4'-diisothiocyanostilbene-2-2'-disulfonic acid (DIDS), is functional under resting conditions.
从大鼠空肠分离出的肠上皮细胞，针对Cl⁻/HCO₃⁻交换的存在进行了测试，此前已在基底外侧膜囊泡中得到证实，但在刷状缘中未得到证实。发现这些细胞能够长时间保持功能完整性和运输能力，足以测量Cl⁻通量。外流和摄取实验均表明，一种受4,4'-二异硫氰基芪-2,2'-二磺酸（DIDS）抑制的Cl⁻/HCO₃⁻反向转运体在静息条件下起作用。
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