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Multidrug resistance pumps in bacteria: variations on a theme.细菌中的多药耐药泵：同一主题的变体
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A thioredoxin gene fusion expression system that circumvents inclusion body formation in the E. coli cytoplasm.一种可避免在大肠杆菌细胞质中形成包涵体的硫氧还蛋白基因融合表达系统。
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Autogenous transcriptional activation of a thiostrepton-induced gene in Streptomyces lividans.硫链丝菌素诱导的天蓝色链霉菌基因的自体转录激活
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Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated.枯草芽孢杆菌的两种高度相似的多药转运蛋白，其表达受到差异调节。
J Bacteriol. 1995 Jul;177(14):3904-10. doi: 10.1128/jb.177.14.3904-3910.1995.
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The MerR metalloregulatory protein binds mercuric ion as a tricoordinate, metal-bridged dimer.MerR金属调节蛋白作为一种三配位、金属桥连二聚体结合汞离子。
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Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system.枯草芽孢杆菌中由外排介导的多药耐药性：与哺乳动物系统的异同
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Untwist and shout: a heavy metal-responsive transcriptional regulator.解开缠绕并呼喊：一种重金属响应转录调节因子。
J Bacteriol. 1992 May;174(10):3097-101. doi: 10.1128/jb.174.10.3097-3101.1992.

多药响应转录调节因子BmrR的药物结合活性位于其C末端结构域。

The drug-binding activity of the multidrug-responding transcriptional regulator BmrR resides in its C-terminal domain.

作者信息

Markham P N, Ahmed M, Neyfakh A A

机构信息

Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago 60612, USA.

出版信息

J Bacteriol. 1996 Mar;178(5):1473-5. doi: 10.1128/jb.178.5.1473-1475.1996.

DOI:10.1128/jb.178.5.1473-1475.1996
PMID:8631728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC177825/
Abstract

Rhodamine and tetraphenylphosphonium, the substrates of the Bacillus subtilis multidrug efflux transporter Bmr, induce the expression of Bmr through direct interaction with its transcriptional activator BmrR. Here we show that the C-terminal domain of BmrR, expressed individually, binds both these compounds and therefore can be used as a model for molecular analysis of the phenomenon of multidrug recognition.

摘要

若丹明和四苯基鏻是枯草芽孢杆菌多药外排转运蛋白Bmr的底物，它们通过与转录激活因子BmrR直接相互作用来诱导Bmr的表达。我们在此表明，单独表达的BmrR的C末端结构域能结合这两种化合物，因此可作为多药识别现象分子分析的模型。