Zouros E, Golding G B, MacKay T F
Genetics. 1977 Mar;85(3):543-50. doi: 10.1093/genetics/85.3.543.
When alleles are combined into few detectable classes, linkage correlations are underestimated most of the time. The probability that the linkage correlation will be underestimated is a function of the actual degree of correlation and the evenness of the allelic distribution, but is mainly determined by the distribution of alleles into distinguishable classes. With only two alleles per class this probability will usually be higher than 0.7. Also, the consistency in the sign of the linkage disequilibrium over many populations may escape detection. An increase of sample size by one order of magnitude or more may be required to compensate for the loss in detection power. It follows that the available electrophoretic studies of linkage correlations, although negative in their majority, do not suggest that epistatic interactions and linkage disequilibria are rare in natural populations.
当等位基因组合成少数可检测的类别时，连锁相关性在大多数情况下会被低估。连锁相关性被低估的概率是实际相关程度和等位基因分布均匀性的函数，但主要由等位基因在可区分类别中的分布决定。每个类别只有两个等位基因时，这种概率通常会高于0.7。此外，许多群体中连锁不平衡符号的一致性可能无法被检测到。可能需要将样本量增加一个数量级或更多，以弥补检测能力的损失。因此，现有的关于连锁相关性的电泳研究，尽管大多数结果为阴性，但并不表明上位性相互作用和连锁不平衡在自然群体中很少见。
