Jiang C H, Lindström S
Department of Cell Biology, University of Linköping, Linköping, Sweden.
J Urol. 1996 Apr;155(4):1477-81.
Intravesical electrical stimulation (IVES) has been used clinically to treat patients with voiding disorders. The aim of the present experimental study was to obtain objective evidence of a modulation of the micturition reflex by intravesical electrical stimulation (IVES).
Forty-one female rats, anesthetized by alpha-chloralose were used for the experiments. Intravesical electrical stimulation was given by a catheter electrode in the bladder (5 minutes of continuous stimulation at 20 Hz, 7 to 11 mA). The effect was evaluated by the change in cystometric micturition threshold volume.
The threshold volume of the micturition reflex decreased significantly to 82% of controls after IVES (p<0.001; n=31). The effect was reversible and lasted for about 1 hour. The decrease was prevented by a transient blockade of the bladder nerves during IVES.
Intravesical electrical stimulation induced a prolonged modulation of the micturition reflex in anesthetized rats. The effect was due to activation of bladder mechanoreceptor afferents and remained long after the period of stimulation. It is proposed that the modulation was due to a prolonged enhancement of excitatory synaptic transmission in the central micturition reflex pathway. Such a modulation may underlie the curative effect of IVES in certain voiding disorders.
膀胱内电刺激（IVES）已在临床上用于治疗排尿障碍患者。本实验研究的目的是获得膀胱内电刺激（IVES）对排尿反射调节作用的客观证据。
使用41只经α-氯醛糖麻醉的雌性大鼠进行实验。通过膀胱内的导管电极给予膀胱内电刺激（以20Hz、7至11mA连续刺激5分钟）。通过膀胱测压排尿阈值体积的变化来评估效果。
IVES后，排尿反射的阈值体积显著降低至对照组的82%（p<0.001；n=31）。该效果是可逆的，持续约1小时。在IVES期间通过短暂阻断膀胱神经可防止这种降低。
膀胱内电刺激在麻醉大鼠中诱导了排尿反射的长期调节。该效果是由于膀胱机械感受器传入神经的激活，并且在刺激期后仍持续很长时间。提出这种调节是由于中枢排尿反射通路中兴奋性突触传递的长期增强。这种调节可能是IVES在某些排尿障碍中疗效的基础。
