Koike M, Ishiyama T, Yokoyama A, Kawakami K, Nakamaki T, Tomoyasu S, Tsuruoka N
Department of Hematology, Showa University School of Medicine, Tokyo, Japan.
Leuk Res. 1995 Dec;19(12):915-20. doi: 10.1016/0145-2126(95)00083-6.
A patient with myelodysplastic syndromes (MDS) developed eosinophilia during treatment with recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF). To study the mechanism of this eosinophilia, we investigated the proliferation of eosinophil colony-forming units (CFU-Eo) in nine patients and four healthy controls. Eosinophil clusters increased significantly in the patients (P < 0.01) compared with controls, but eosinophil colonies were not different between controls and MDS patients. In addition, the eosinophil clusters were significantly increased with rhGM-CSF in MDS patients compared with controls, although serum GM-CSF concentrations were similar in both groups. These results suggest that eosinophil clusters are increased in MDS either through abnormal progenitor proliferation or hypersensitivity to GM-CSF.
一名骨髓增生异常综合征（MDS）患者在接受重组人粒细胞-巨噬细胞集落刺激因子（rhGM-CSF）治疗期间出现嗜酸性粒细胞增多。为研究这种嗜酸性粒细胞增多的机制，我们调查了9例患者和4名健康对照者中嗜酸性粒细胞集落形成单位（CFU-Eo）的增殖情况。与对照组相比，患者的嗜酸性粒细胞簇显著增加（P < 0.01），但对照组和MDS患者之间的嗜酸性粒细胞集落并无差异。此外，与对照组相比，MDS患者使用rhGM-CSF后嗜酸性粒细胞簇显著增加，尽管两组血清GM-CSF浓度相似。这些结果表明，MDS患者中嗜酸性粒细胞簇增加，要么是由于祖细胞异常增殖，要么是对GM-CSF过敏。
