Risold P Y, Swanson L W
Program in Neural, Informational, and Behavioral Sciences, University of Southern California, Los Angeles 90089-2520, USA.
Science. 1996 Jun 7;272(5267):1484-6. doi: 10.1126/science.272.5267.1484.
The hippocampus has two major outputs: multisynaptic pathways to the cerebral cortex and a massive descending projection directly to the lateral septal part of the basal ganglia. Here it is shown that the descending output is organized in such a way that different hippocampal regions map in an orderly way onto hypothalamic systems mediating the expression of different classes of goal-oriented behavior. This mapping is characterized by a unidirectional hippocampo-lateral septal projection and then by bidirectional lateral septo-hypothalamic projections, all topographically organized. The connectional evidence predicts that information processing in different regions of the hippocampus selectively influences the expression of different classes of behavior.
一条是通向大脑皮层的多突触通路，另一条是直接投射到基底神经节外侧隔区的大量下行投射。本文表明，下行输出的组织方式是，海马体的不同区域以有序的方式映射到介导不同类型目标导向行为表达的下丘脑系统。这种映射的特征是单向的海马体-外侧隔投射，然后是双向的外侧隔-下丘脑投射，所有这些都是按拓扑结构组织的。连接证据预测，海马体不同区域的信息处理会选择性地影响不同类型行为的表达。
