Chung A K, Michels V, Poland G A, King B F, Wojno K J, Oesterling J E
Department of Urology, Radiology, and Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Urology. 1996 Mar;47(3):448-51. doi: 10.1016/S0090-4295(99)80473-7.
Urologic manifestations of neurofibromatosis type 1 are rare. The most common urologic area of involvement has been the urinary bladder. Prostate involvement in generalized neurofibromatosis has been noted previously in only 10 patients, 3 of whom were adults. Of these 3, 1 had a neurofibroma, 1 had a malignant schwannoma, and 1 patient died before tissue diagnosis could be obtained. The patient discussed in this report is the second known adult patient with biopsy-proven neurofibroma of the prostate gland. In addition, this is the first reported use of endorectal magnetic resonance imaging of the prostate to localize and specify the extent of neurofibromas in these patients.
1型神经纤维瘤病的泌尿系统表现较为罕见。最常受累的泌尿系统部位是膀胱。此前仅在10例患者中发现前列腺受累于全身性神经纤维瘤病，其中3例为成年人。在这3例成年人中，1例患有神经纤维瘤，1例患有恶性神经鞘瘤，1例患者在获得组织诊断前死亡。本报告中讨论的患者是第二例经活检证实患有前列腺神经纤维瘤的已知成年患者。此外，这是首次报道使用前列腺直肠内磁共振成像来定位并明确这些患者中神经纤维瘤的范围。
