新生大鼠甲状腺切除对发育中大鼠脑内核酸和蛋白质含量的影响。

Effect of neonatal thyroidectomy on nucleic acids and protein contents of the developing rat brain.

作者信息

Yamagani S, Kiriike N, Kawakita Y

出版信息

Folia Psychiatr Neurol Jpn. 1977;31(1):119-24. doi: 10.1111/j.1440-1819.1977.tb02689.x.

DOI:10.1111/j.1440-1819.1977.tb02689.x

Abstract

(1) Thyroidectomy at birth caused a temporal reduction of the DNA content only in the cerebellum during the periods from 7 to 21 days after birth, but not in the cerebrum and brain stem. (2) The ratio of RNA to DNA in cerebrum from the thyroidectomized rats was underwent a marked decrease from 14 to 56 days as compared with those of the normal controls. On the other hand, the effect of thyroid deficiency on the ratios of cerebellum and brain stem as a whole was very small. (3) The ratios of protein to DNA generally declined in the three brain regions during the periods from 14 to 56 days as a result of throid deprivation.

摘要

(1) 出生时进行甲状腺切除术，仅在出生后7至21天期间导致小脑DNA含量暂时降低，而大脑和脑干未出现这种情况。(2) 与正常对照组相比，甲状腺切除大鼠大脑中RNA与DNA的比率在14至56天期间显著下降。另一方面，甲状腺功能减退对整个小脑和脑干比率的影响非常小。(3) 由于甲状腺缺乏，在14至56天期间，三个脑区的蛋白质与DNA比率普遍下降。