Riddell R H
McMaster University, Department of Pathology, Hamilton, Ontario, Canada.
Am J Gastroenterol. 1996 May;91(5):864-72.
The definition of a "premalignant" lesion is discussed, together with its relationship to dysplastic change. The definition and description of dysplasia are given. Systems for grading dysplasia are set out, and the clinical implications of these changes are discussed. Although the "dysplasia terminology" in current use remains the gold standard for clinical practice, a series of more recent developments, including the discovery of flat and depressed adenomas, the possibility of de novo carcinoma throughout the gastrointestinal tract, as well as advances in molecular biology, raise the question of whether this terminology will be adequate in future. Other terminologies exist that provide an alternative viewpoint, but none is satisfactory.
本文讨论了“癌前”病变的定义及其与发育异常变化的关系。给出了发育异常的定义和描述。阐述了发育异常的分级系统，并讨论了这些变化的临床意义。尽管目前使用的“发育异常术语”仍是临床实践的金标准，但一系列最新进展，包括扁平及凹陷性腺瘤的发现、全胃肠道新发癌的可能性以及分子生物学的进步，引发了关于该术语在未来是否足够的问题。还存在其他提供不同观点的术语，但都不尽人意。
