Alho O P, Läärä E, Oja H
Department of Otolaryngology, Faculty of Medicine, University of Oulu, Finland.
Am J Epidemiol. 1996 Jun 1;143(11):1149-56. doi: 10.1093/oxfordjournals.aje.a008693.
The aim of this study was to assess the excess risk attributable to alterable risk factors for acute otitis media in Finnish children, including day care attendance, parental smoking, and a short duration of breastfeeding. Data on a population-based cohort of 2,512 children were gathered from medical records and questionnaires from 1985 to 1988. Excess (attributable) fractions for the risk factors were calculated among 825 children (target population) followed for 2 years, from a dynamic logistic model fitted to the entire cohort (estimation data). In theory, one child out of every five affected in the exposed population would have escaped otitis media completely if he/she had been moved from nursery day care to home care, and two out of every five affected could have escaped recurrent episodes in this way. The corresponding figures for family day care were lower: one and two children out of every six affected, respectively. Cessation of parental smoking and breastfeeding would have smaller effects. The impacts were more modest in the whole population. Nevertheless, approximately 14% of all of the otitis media episodes would have been avoided if all of the children had been cared for at home. These figures are hypothetical, since it is unlikely that use of day care outside the home can be avoided altogether, but they offer further evidence of the notable role of day care attendance as a risk factor for otitis media.
本研究旨在评估芬兰儿童急性中耳炎可改变风险因素所致的额外风险,这些因素包括日托 attendance、父母吸烟和母乳喂养时间短。1985年至1988年期间,从医疗记录和问卷中收集了2512名儿童的基于人群队列的数据。根据拟合整个队列(估计数据)的动态逻辑模型,在随访2年的825名儿童(目标人群)中计算了风险因素的超额(归因)分数。理论上,暴露人群中每五名受影响儿童中有一名如果从日托所转到家庭护理,就可以完全避免患中耳炎,每五名受影响儿童中有两名可以通过这种方式避免反复发作。家庭日托的相应数字较低:每六名受影响儿童中分别有一名和两名。父母戒烟和母乳喂养的影响较小。在整个人口中,影响更为适度。然而,如果所有儿童都在家中得到照顾,大约14%的中耳炎发作本可避免。这些数字是假设性的,因为不太可能完全避免使用家庭以外的日托,但它们进一步证明了日托 attendance作为中耳炎风险因素的显著作用。 (注:原文中“day care attendance”表述不完整,可能存在信息缺失)