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食管癌切除术后的症状性快速心律失常:发生率及预后指标

Symptomatic tachydysrhythmias after esophagectomy: incidence and outcome measures.

作者信息

Amar D, Burt M E, Bains M S, Leung D H

机构信息

Department of Anesthesiology and Critical Care Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

出版信息

Ann Thorac Surg. 1996 May;61(5):1506-9. doi: 10.1016/0003-4975(96)00111-7.

DOI:10.1016/0003-4975(96)00111-7
PMID:8633967
Abstract

BACKGROUND

Supraventricular tachydysrhythmias (SVT) after esophageal operations for carcinoma occur frequently and may be associated with increased morbidity. Prospective data on the etiology, incidence, and importance of these dysrhythmias are sparse.

METHODS

In 100 consecutive patients undergoing esophagectomy without prior history of atrial dysrhythmias or receiving antiarrhythmics, we prospectively examined the effects of predefined risk factors by history and pulmonary function on the 30-day incidence of symptomatic postoperative SVT, need for intensive care unit admission, and mortality rate.

RESULTS

Symptomatic postoperative SVT occurred in 13 (13%) of the 100 patients studied at a median of 3 days after operation and was accompanied by hypotension in 9/13 (69%). Univariate correlates of SVT were older age (p = 0.03), perioperative use of theophylline (p = 0.044), and a low carbon monoxide diffusion capacity (measured in 56% of patients) on preoperative pulmonary function. Patients in whom SVT developed had a higher rate of intensive care unit admission (p = 0.0001) and a longer hospital stay (p = 0.036). Although patients in whom SVT developed had a higher (p = 0.013) 30-day mortality rate, SVT was not the direct cause of death.

CONCLUSIONS

These prospective data show that the true incidence of symptomatic SVT within 30 days of esophagectomy is lower than previously reported. Occurrence of SVT was associated with significant morbidity. Older age was the strongest predictor of SVT after esophagectomy. In high-risk patients, continued monitoring (48 to 72 hours) and early interventions to decrease the incidence of postoperative SVT may improve overall surgical outcomes.

摘要

背景

食管癌手术后室上性快速心律失常(SVT)频繁发生,可能与发病率增加有关。关于这些心律失常的病因、发病率及重要性的前瞻性数据较少。

方法

对100例连续接受食管切除术且既往无心律失常病史或未服用抗心律失常药物的患者,我们通过病史和肺功能前瞻性地研究了预先定义的危险因素对术后30天有症状的SVT发生率、入住重症监护病房的需求及死亡率的影响。

结果

在研究的100例患者中,13例(13%)术后出现有症状的SVT,中位时间为术后3天,其中9/13例(69%)伴有低血压。SVT的单因素相关因素为年龄较大(p = 0.03)、围手术期使用茶碱(p = 0.044)以及术前肺功能检查中一氧化碳弥散量较低(56%的患者进行了此项检查)。发生SVT的患者入住重症监护病房的比例较高(p = 0.0001),住院时间较长(p = 0.036)。尽管发生SVT的患者30天死亡率较高(p = 0.013),但SVT并非直接死因。

结论

这些前瞻性数据表明,食管切除术后30天内有症状的SVT的实际发生率低于先前报道。SVT的发生与显著的发病率相关。年龄较大是食管切除术后SVT的最强预测因素。在高危患者中,持续监测(48至72小时)并早期干预以降低术后SVT的发生率可能会改善总体手术结局。

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