Polycondensed nitrogen heterocycles. Part 27. Indolo[3,2-c]cinnoline. Synthesis and antileukemic activity.
作者信息
Cirrincione G, Almerico A M, Diana P, Grimaudo S, Dattolo G, Aiello E, Barraja P, Mingoia F
机构信息
Istituto Farmacochimico, Università degli Studi, Palermo.
出版信息
Farmaco. 1995 Dec;50(12):849-52.
PMID:8634075
Abstract
Indolo[3,2-c]cinnolines of type 5, variously substituted either in the indole and in the cinnoline moieties, were prepared in good overall yields, by intramolecular cyclization of indolo derivatives 4. Compounds 5a-d showed a good cytotoxic activity against FLC and K562 leukemic cell lines, both sensitive and multi-drug resistant.
摘要
Zotero 插件