Kim S Y, Berger D, Yim S O, Sacks P G, Tainsky M A
Department of Tumor Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Mol Carcinog. 1996 May;16(1):6-11. doi: 10.1002/(SICI)1098-2744(199605)16:1<6::AID-MC2>3.0.CO;2-I.
Retinoic acid (RA) modulates the growth and differentiation of various normal and malignant cells. These effects are most likely mediated by changes in gene expression. Genes whose expression is modulated by RA may be useful as markers of growth responsiveness to retinoids. Using differential cDNA cloning we identified 10 genes regulated by RA in the head and neck squamous cell carcinoma cell line MDA886Ln. Keratin (K) 13 gene expression was the gene expression most related to the degree of sensitivity of growth to RA, as K13 was not expressed in a series of RA-resistant cell lines. Our data suggest that low K13 expression may be mechanistically related to resistance to RA-induced growth inhibition.
维甲酸（RA）可调节多种正常细胞和恶性细胞的生长与分化。这些效应很可能是由基因表达的变化介导的。其表达受RA调节的基因可能可用作生长对维甲酸反应性的标志物。通过差异cDNA克隆，我们在头颈部鳞状细胞癌细胞系MDA886Ln中鉴定出10个受RA调节的基因。角蛋白（K）13基因表达是与生长对RA的敏感程度最相关的基因表达，因为在一系列RA抗性细胞系中K13不表达。我们的数据表明，低K13表达可能在机制上与对RA诱导的生长抑制的抗性有关。
