高效液相色谱法测定澳大利亚市场上销售的药物剂型中比沙可啶的含量。
High-performance liquid chromatographic determination of bisacodyl in pharmaceutical dosage forms marketed in Australia.
作者信息
Bradshaw K M, Burnett J, Sidhu A S
机构信息
Pharmaceutical Chemistry Section, Therapeutic Goods Administration Laboratories, Woden, Australia.
出版信息
J Pharm Biomed Anal. 1995 Oct;13(11):1355-62. doi: 10.1016/0731-7085(95)01547-x.
PMID:8634353
Abstract
HPLC methods have been developed for the assay of bisacodyl in various pharmaceutical forms. The extraction procedures are simple and the HPLC conditions separate bisacodyl from its degradation products. The chromatography was performed using a Merck LiChrospher RP-select B column, a mobile phase of 55% acetonitrile/45% 0.05 M KH2PO4 and detection by UV at 214 nm.
摘要
已经开发出高效液相色谱（HPLC）方法用于测定各种药物剂型中的比沙可啶。提取程序简单，且HPLC条件能将比沙可啶与其降解产物分离。使用默克LiChrospher RP-select B柱进行色谱分析，流动相为55%乙腈/45% 0.05M磷酸二氢钾，并在214nm处通过紫外光进行检测。
Zotero 插件