Müller W D, Karamfilov T, Bufe A, Fahlbush B, Wolf I, Jäger L
Institut für Klinische Immunologie, Friedrich-Schiller-Universität, Jena, Germany.
Int Arch Allergy Immunol. 1996 Apr;109(4):352-5. doi: 10.1159/000237262.
Selected human T cell clones reactive with group 5 allergens of timothy grass (Phl p 5) were cross-stimulated in specific proliferation assays with group 1 allergens of rye grass (Lol p 1). Such interspecies cross-reactivities result obviously from structural motifs presented on defined Phl p 5 fragments as shown with recombinant Phl p 5 products.
选择与梯牧草第5组过敏原(Phl p 5)反应的人T细胞克隆,在特异性增殖试验中用黑麦草第1组过敏原(Lol p 1)进行交叉刺激。如重组Phl p 5产物所示,这种种间交叉反应显然源于特定Phl p 5片段上呈现的结构基序。