Bukin Y V, Draudin-Krylenko V A, Orlov E N, Kuvshinov Y P, Poddubny B K, Vorobyeva O V, Shabanov M A
Department of Cancer Epidemiology and Prevention, Cancer Research Center of Russian Academy of Medical Sciences, Moscow, Russia.
Cancer Epidemiol Biomarkers Prev. 1995 Dec;4(8):865-70.
The effect of beta-carotene and DL-alpha-tocopheryl acetate (alpha-TAc) on the activity of ornithine decarboxylase (ODC) in human atrophic stomach mucosa and intestinal metaplasia (IM) was studied in a double-blind intervention trial. Persons (227) with upper gastrointestinal symptoms and/or atrophic gastritis (AG) were examined. It was found that ODC activity in the biopsies of antral mucosa increased gradually from normal mucosa (7.2 +/- 1.8 units) to superficial gastritis (22.7 +/- 5.9 units) and to AG (54.2 +/- 6.9 units). Enzyme activity in cases of IM did not differ from atrophic mucosa without IM (56.1 +/- 8.0 versus 51.4 +/- 5.6 units; P > 0.05). For the intervention trial, 3 groups of 20 patients with AG were studied. Patients were supplemented daily for 1 year with beta-C (20 mg; group 1), alpha-TAc (55 mg; group 2), or placebo (group 3). No significant change in ODC activity was observed in placebo-treated subjects during 1-year follow-up. During the first 3 months, beta-C supplementation resulted in about a 50% decrease in ODC activity in atrophic mucosa. A moderate decrease in ODC activity of approximately 18% was observed after 6 months supplementation with alpha-TAc. The possible role of ODC in gastric carcinogenesis is discussed.
在一项双盲干预试验中，研究了β-胡萝卜素和DL-α-生育酚醋酸酯（α-TAc）对人萎缩性胃黏膜和肠化生（IM）中鸟氨酸脱羧酶（ODC）活性的影响。对227名有上消化道症状和/或萎缩性胃炎（AG）的人进行了检查。发现胃窦黏膜活检中的ODC活性从正常黏膜（7.2±1.8单位）逐渐增加到浅表性胃炎（22.7±5.9单位）和AG（54.2±6.9单位）。IM患者的酶活性与无IM的萎缩性黏膜患者无差异（56.1±8.0对51.4±5.6单位；P>0.05）。在干预试验中，对3组每组20名AG患者进行了研究。患者每天补充β-C（20毫克；第1组）、α-TAc（55毫克；第2组）或安慰剂（第3组），为期1年。在1年的随访中，安慰剂治疗的受试者ODC活性未观察到显著变化。在最初3个月，补充β-C导致萎缩性黏膜中ODC活性降低约50%。补充α-TAc 6个月后，观察到ODC活性适度降低约18%。讨论了ODC在胃癌发生中的可能作用。
