Sápi Z, Lukács G, Sztán M, Papp J, Oláh E
Department of Pathology, St. John's Hospital, Budapest, Hungary.
Diagn Mol Pathol. 1995 Dec;4(4):256-60.
Alterations of p53 suppressor gene as a possible indicator of the metastatic potential of thyroid carcinomas were evaluated in a cohort of 45 thyroid carcinomas. Well-differentiated papillary and follicular carcinomas were evaluated; the poorly differentiated and the undifferentiated forms were excluded from the studies. Tumors were divided into two groups: those giving no metastasis for > 10 years and those developing metastasis within 5 years. Gene alterations were tested by immunocytochemical detection of p53 gene expression and by determining loss of heterozygosity (LOH). Considering the two methods together, p53 damages were observed in two out of 11 papillary carcinomas without metastasis (18.1%), one out of nine papillary carcinomas with metastasis (11.1%), two out of 14 follicular carcinomas without metastasis (14.2%), and five out of 11 follicular carcinomas with metastasis (45.4%). Statistical X2 test showed significantly (p = 0.05) only between follicular carcinomas with and without metastasis thus p53 damage may have an impact for metastatic potential of follicular thyroid carcinomas.
在一组45例甲状腺癌中，评估了p53抑癌基因改变作为甲状腺癌转移潜能的一种可能指标。对高分化乳头状癌和滤泡状癌进行了评估；低分化和未分化形式被排除在研究之外。肿瘤分为两组：那些10年以上无转移的和那些5年内发生转移的。通过免疫细胞化学检测p53基因表达和确定杂合性缺失（LOH）来检测基因改变。综合考虑这两种方法，在11例无转移的乳头状癌中有2例（18.1%）观察到p53损伤，9例有转移的乳头状癌中有1例（11.1%），14例无转移的滤泡状癌中有2例（14.2%），11例有转移的滤泡状癌中有5例（45.4%）。统计学X²检验仅在有转移和无转移的滤泡状癌之间显示出显著差异（p = 0.05），因此p53损伤可能对滤泡状甲状腺癌的转移潜能有影响。
