Yamamoto K, Hayashi J, Miyamura H, Eguchi S
Second Department of Surgery, Niigata University School of Medicine, Japan.
Cardiovasc Surg. 1996 Feb;4(1):9-14. doi: 10.1016/0967-2109(96)83777-x.
The effects of fresh autologous platelet-rich plasma and autologous whole blood on haemostasis after cardiopulmonary bypass were examined in adult cardiac surgery patients. Platelet count, adenosine diphosphate 10 microM maximum aggregation rate and clotting Factor VIII were greater in the platelet-rich plasma group (n = 11) than in the whole blood group (n = 8) after platelet-rich plasma or whole blood reinfusion. Blood loss after heparin neutralization was less in the platelet-rich plasma group than in the whole blood group. Blood loss from heparin neutralization to 12h after surgery was correlated with platelet count, fibrinogen and ADP aggregation rate. The number of patients who required homologous blood transfusion was less in the platelet-rich plasma group. In conclusion, the reinfusion of autologous platelet-rich plasma improves haemostasis after cardiopulmonary bypass, and may enable surgery to be performed without homologous blood transfusion.
在成年心脏手术患者中，研究了新鲜自体富血小板血浆和自体全血对体外循环后止血的影响。富血小板血浆组（n = 11）在输注富血小板血浆或全血后，血小板计数、10微摩尔二磷酸腺苷最大聚集率和凝血因子VIII均高于全血组（n = 8）。富血小板血浆组肝素中和后的失血量少于全血组。肝素中和至术后12小时的失血量与血小板计数、纤维蛋白原和ADP聚集率相关。富血小板血浆组需要输注同源血的患者数量较少。总之，自体富血小板血浆的回输可改善体外循环后的止血情况，并可能使手术无需输注同源血即可进行。
