Malizia A L, Nutt D J
Psychopharmacology Unit, School of Medical Sciences, University of Bristol, England.
Clin Neuropharmacol. 1995 Jun;18(3):215-32. doi: 10.1097/00002826-199506000-00002.
Flumazenil is a benzodiazepine receptor antagonist. It is currently used mainly in the anaesthetic and emergency rooms to reverse the effect of exogenous benzodiazepines. Its use in a variety of experimental animal models and in human neuropsychiatric disorders continues to generate a wealth of information on the possible role of the benzodiazepine-GABA(A) receptor complex in their pathogenesis. In addition, labelled with carbon-11, flumazenil has proved to be one of the most successful positron emission tomography ligands stimulating research on the role of the benzodiazepine receptor in these disorders. This review focuses on the current state of play of flumazenil as a therapeutic or investigative agent in neuropsychiatry, citing also the relevant animal models.
氟马西尼是一种苯二氮䓬受体拮抗剂。它目前主要用于麻醉和急诊室，以逆转外源性苯二氮䓬的作用。它在各种实验动物模型和人类神经精神疾病中的应用，持续产生了大量关于苯二氮䓬 - GABA(A) 受体复合物在其发病机制中可能作用的信息。此外，用碳 - 11 标记的氟马西尼，已被证明是最成功的正电子发射断层扫描配体之一，激发了对苯二氮䓬受体在这些疾病中作用的研究。本综述重点关注氟马西尼作为神经精神病学治疗或研究药物的现状，同时也引用了相关的动物模型。
