氟哌啶醇对血浆卡马西平水平的药物相互作用效应。
The drug-drug interaction effects of haloperidol on plasma carbamazepine levels.
作者信息
Iwahashi K, Miyatake R, Suwaki H, Hosokawa K, Ichikawa Y
机构信息
Department of Neuropsychiatry, Kagawa Medical School, Japan.
出版信息
Clin Neuropharmacol. 1995 Jun;18(3):233-6. doi: 10.1097/00002826-199506000-00003.
The metabolic interaction between carbamazepine (CBZ) and haloperidol (HP) was studied in Japanese schizophrenic patients treated with HP but not with CBZ and with both CBZ and HP. The serum CBZ concentrations in patients treated without HP were significantly decreased (p < 0.05), on average approximately 40%, as compared to those in patients treated with both CBZ and HP, whereas the serum HP concentrations in patients treated with both HP and CBZ were significantly decreased (p < 0.05), as compared to those in patients treated with HP but not with CBZ. The effect of HP, which prevents the serum CBZ level from decreasing, was shown in this study.
在未服用卡马西平（CBZ）但服用氟哌啶醇（HP）以及同时服用CBZ和HP的日本精神分裂症患者中，研究了CBZ与HP之间的代谢相互作用。与同时服用CBZ和HP的患者相比，未服用HP的患者血清CBZ浓度显著降低（p < 0.05），平均降低约40%；而与服用HP但未服用CBZ的患者相比，同时服用HP和CBZ的患者血清HP浓度显著降低（p < 0.05）。本研究显示了HP可防止血清CBZ水平降低的作用。
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