Hilman B C, Aitken M L, Constantinescu M
LSUMC, Department of Pediatrics, Shreveport, 71130-3932, USA.
Clin Obstet Gynecol. 1996 Mar;39(1):70-86. doi: 10.1097/00003081-199603000-00008.
With increasing life span of patients with CF, more women with CF are becoming pregnant and others are seeking information about the risks involved during pregnancy and delivery. A striking limitation of the available information is the lack of large prospective studies of pregnant patients with CF matched for age and disease severity compared with their non-pregnant cohorts. A study investigating the effect of pregnancy on morbidity and mortality is being completed by the Cystic Fibrosis Foundation. We recommend that all women with CF be offered contraceptive measures and counseling on the maternal and fetal risks of pregnancy, including the genetic risks for the child. The issue of who will raise the child in the event of subsequent morbidity or maternal mortality should ideally be prospectively discussed.
随着囊性纤维化（CF）患者寿命的延长，越来越多的CF女性怀孕，还有一些人在寻求有关怀孕和分娩期间所涉风险的信息。现有信息的一个显著局限是，缺乏对年龄和疾病严重程度相匹配的CF孕妇与其未怀孕队列进行比较的大型前瞻性研究。囊性纤维化基金会正在完成一项调查怀孕对发病率和死亡率影响的研究。我们建议为所有CF女性提供避孕措施，并就怀孕对母婴的风险进行咨询，包括孩子的遗传风险。理想情况下，应该前瞻性地讨论在随后出现发病情况或产妇死亡时由谁来抚养孩子的问题。
