使用固定化合成肽鉴定人白细胞介素-6与其受体之间的接触位点。
Use of immobilized synthetic peptides for the identification of contact sites between human interleukin-6 and its receptor.
作者信息
Weiergräber O, Schneider-Mergener J, Grötzinger J, Wollmer A, Küster A, Exner M, Heinrich P C
机构信息
Institut für Biochemie der RWTH Aachen, Germany.
出版信息
FEBS Lett. 1996 Jan 29;379(2):122-6. doi: 10.1016/0014-5793(95)01482-9.
PMID:8635575
Abstract
Synthetic peptides immobilized on cellulose membranes proved to be a powerful tool for the identification of sites in the cytokine IL-6 involved in receptor binding. Similarly, a region in the extracellular part of the IL-6 receptor which is important for interaction with its ligand was identified.
摘要
固定在纤维素膜上的合成肽被证明是鉴定细胞因子白细胞介素-6（IL-6）中参与受体结合位点的有力工具。同样，也鉴定出了IL-6受体细胞外部分中对于与配体相互作用很重要的一个区域。
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