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Sodium binding sites of gramicidin A: sodium-23 nuclear magnetic resonance study.

作者信息

Cornélis A, Laszlo P

出版信息

Biochemistry. 1979 May 15;18(10):2004-7. doi: 10.1021/bi00577a025.

DOI:10.1021/bi00577a025
PMID:86363
Abstract

In ethanol-water mixtures (90:10), the gramicidin dimer binds Na+ cations at well-defined sites, with a binding constant K = 4 M-1. Partial desolvation of Na+ occurs upon binding, as judged from the magnitude of the quadrupolar coupling constant (1.7 MHz) for bound sodium. The binding sites are identified with the outer sites flanking the channel entrances. The rate constants for binding and release are k+ less than or equal to 2.2 X 10(9) M-1 s-1 and k- less than or equal to 5.5 X 10(8) s-1, respectively.

摘要

相似文献

1
Sodium binding sites of gramicidin A: sodium-23 nuclear magnetic resonance study.
Biochemistry. 1979 May 15;18(10):2004-7. doi: 10.1021/bi00577a025.
2
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3
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4
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6
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7
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8
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10
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引用本文的文献

1
Binding of alkaline cations to the double-helical form of gramicidin.碱性阳离子与短杆菌肽双螺旋形式的结合。
Biophys J. 1996 Jul;71(1):163-70. doi: 10.1016/S0006-3495(96)79213-5.
2
Binding constants of Li+, K+, and Tl+ in the gramicidin channel determined from water permeability measurements.通过水渗透性测量确定的短杆菌肽通道中Li⁺、K⁺和Tl⁺的结合常数。
Biophys J. 1981 Aug;35(2):485-99. doi: 10.1016/S0006-3495(81)84804-7.
3
The malonyl gramicidin channel: NMR-derived rate constants and comparison of calculated and experimental single-channel currents.
丙二酰短杆菌肽通道：核磁共振衍生的速率常数以及计算与实验单通道电流的比较。
J Membr Biol. 1980 Jun 30;55(1):29-51. doi: 10.1007/BF01926368.
4
Rate theory calculation of gramicidin single-channel currents using NMR-derived rate constants.使用核磁共振衍生速率常数对短杆菌肽单通道电流进行速率理论计算。
Proc Natl Acad Sci U S A. 1980 Apr;77(4):2028-32. doi: 10.1073/pnas.77.4.2028.
5
Equilibrium binding constants for the group I metal cations with gramicidin-A determined by competition studies and T1+-205 nuclear magnetic resonance spectroscopy.通过竞争研究和T1+-205核磁共振光谱法测定的第一主族金属阳离子与短杆菌肽A的平衡结合常数。
Biophys J. 1986 Sep;50(3):539-44. doi: 10.1016/S0006-3495(86)83492-0.
6
Nuclear magnetic resonance of 23Na ions interacting with the gramicidin channel.与短杆菌肽通道相互作用的23Na离子的核磁共振
Biophys J. 1985 Oct;48(4):643-62. doi: 10.1016/S0006-3495(85)83820-0.
7
Sodium-23 and potassium-39 nuclear magnetic resonance relaxation in eye lens. Examples of quadrupole ion magnetic relaxation in a crowded protein environment.眼晶状体中钠-23和钾-39的核磁共振弛豫。拥挤蛋白质环境中四极离子磁弛豫的实例。
Biophys J. 1992 May;61(5):1061-75. doi: 10.1016/S0006-3495(92)81916-1.