Maniatis A N, Palermos J, Kantzanou M, Maniatis N A, Christodoulou C, Legakis N J
Department of Microbiology, Medical School, University of Athens, Greece.
J Med Microbiol. 1996 Mar;44(3):199-202. doi: 10.1099/00222615-44-3-199.
The significance of Streptococcus agalactiae as an aetiological agent in vaginitis was evaluated. A total of 6226 samples from women who presented with vaginal symptoms was examined. The presence of >10 leucocytes/high-power field (h.p.f.) was taken to be the criterion of active infection. S. agalactiae was isolated from 10.1% of these samples. The isolation rates of other common pathogens such as Candida spp., Gardnerella vaginalis and Trichomonas spp. were 54.1%, 27.2% and 4.2%, respectively, in the same group of patients. In contrast, the isolation rates of these micro-organisms in the group of patients who had no infection (<10 leucocytes/h.p.f.) were 4.2%, 38.3%, 33% and 0.5%, respectively. In the majority of samples from which S. agalactiae was isolated, it was the sole pathogen isolated (83%) and its presence was associated with an inflammatory response in 80% of patients. Furthermore, the relative risk of vaginal infection with S. agalactiae (2.38) in patients with purulent vaginal discharge was greater than that of Candida spp. infection (1.41) and lower than that of Trichomonas spp. infection (8.32). These data suggest that S. agalactiae in symptomatic women with microscopic evidence of inflammation should be considered a causative agent of vaginitis.
评估了无乳链球菌作为阴道炎病原体的意义。共检查了6226例有阴道症状女性的样本。以每高倍视野白细胞数>10个作为活动性感染的标准。从10.1%的这些样本中分离出了无乳链球菌。在同一组患者中，其他常见病原体如念珠菌属、阴道加德纳菌和滴虫属的分离率分别为54.1%、27.2%和4.2%。相比之下，在无感染（每高倍视野白细胞数<10个）的患者组中，这些微生物的分离率分别为4.2%、38.3%、33%和0.5%。在大多数分离出无乳链球菌的样本中，它是唯一分离出的病原体（83%），并且在80%的患者中其存在与炎症反应相关。此外，脓性阴道分泌物患者感染无乳链球菌的相对风险（2.38）大于念珠菌属感染（1.41），低于滴虫属感染（8.32）。这些数据表明，在有显微镜下炎症证据的有症状女性中，无乳链球菌应被视为阴道炎的病原体。
