The location of MZF-1 at the telomere of human chromosome 19q makes it vulnerable to degeneration in aging cells.

作者信息

Hoffman S M, Hromas R, Amemiya C, Mohrenweiser H W

机构信息

Human Genome Center, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA.

出版信息

Leuk Res. 1996 Mar;20(3):281-3. doi: 10.1016/0145-2126(95)00158-1.

DOI:10.1016/0145-2126(95)00158-1

PMID:8637224

Abstract

A zinc-finger gene encoding a transcription factor that regulates hematopoiesis, MZF-1, is located at the extreme end of the q arm of human chromosome 19. Several lines of evidence indicate that MZF-1 lies less than 20 kb from the subtelomeric repeat region of 19q. Telomeres are known to degenerate as cells age; disruption of MZF-1 due to telomeric degeneration may play a role in the increased incidence of leukemia in the elderly.

摘要