多烯大环内酯类抗生素对无脊椎动物组织培养细胞的影响。

Effect of polyene macrolide antibiotics on invertebrate tissue culture cells.

作者信息

Goldstein N I, Fisher P B, Schaffner C P

出版信息

J Antibiot (Tokyo). 1977 Apr;30(4):321-5. doi: 10.7164/antibiotics.30.321.

DOI:10.7164/antibiotics.30.321

Abstract

The effect of amphotericin B (AB) and amphotericin B methyl ester (AME) on viability and DNA synthesis in three insect cell lines, Trichoplusia ni (Tn) Carpocapsa pomonella 169 (Cp) and Aedes aegypti (Aa), has been evaluated. In all cases AME was less toxic than AB and inhibited DNA synthesis to a lesser degree than AB. However, the three cell lines differed in their response to the two polyene macrolide antibiotic preparations. Tn and Aa cell responded in a similar manner when exposed to either AME or AB, whereas Cp cells were more sensitive to both antibiotics than Tn or Aa cells.

摘要

已评估两性霉素B（AB）和两性霉素B甲酯（AME）对三种昆虫细胞系，即粉纹夜蛾（Tn）、苹果蠹蛾169（Cp）和埃及伊蚊（Aa）的活力及DNA合成的影响。在所有情况下，AME的毒性均低于AB，且对DNA合成的抑制程度也低于AB。然而，这三种细胞系对这两种多烯大环内酯类抗生素制剂的反应有所不同。当暴露于AME或AB时，Tn和Aa细胞的反应相似，而Cp细胞对这两种抗生素的敏感性均高于Tn或Aa细胞。