Burrell H C, Sibbering D M, Wilson A R, Pinder S E, Evans A J, Yeoman L J, Elston C W, Ellis I O, Blamey R W, Robertson J F
Department of Radiology, City Hospital, Nottingham, England.
Radiology. 1996 Jun;199(3):811-7. doi: 10.1148/radiology.199.3.8638010.
To review the mammographic features of screening interval breast cancers and to compare the tumor size, histologic grade, and lymph node involvement with those in screening-detected and unscreened symptomatic cancers.
Screening mammography was performed in 72,773 women aged 50-64 years. Ninety interval cancers were identified in 89 women. The mammographic and histopathologic features of these cancers were analyzed.
At review of the screening mammograms, interval cancers were classified into four groups: 51 true-positive, 20 false-negative, seven mammographically occult, and 12 unclassified. The most common missed abnormality in the false-negative cases was architectural distortion. Interval cancers were larger, of higher grade, and more likely to have lymph node involvement than screening-detected tumors and were of similar size, histologic grade, and stage of lymph node involvement as symptomatic tumors.
Prognosis in interval cancers is similar to that in symptomatic, unscreened tumors and statistically significantly worse than that in screening-detected cancers.
回顾筛查间期乳腺癌的乳腺钼靶特征，并将肿瘤大小、组织学分级及淋巴结受累情况与筛查发现的和未筛查的有症状乳腺癌进行比较。
对72773名年龄在50 - 64岁的女性进行乳腺钼靶筛查。在89名女性中发现了90例间期癌。分析了这些癌症的乳腺钼靶和组织病理学特征。
复查乳腺钼靶片时，间期癌分为四组：51例真阳性、20例假阴性、7例钼靶隐匿性及12例未分类。假阴性病例中最常见的漏诊异常是结构扭曲。间期癌比筛查发现的肿瘤更大、分级更高且更易出现淋巴结受累，其大小、组织学分级及淋巴结受累分期与有症状肿瘤相似。
间期癌的预后与有症状、未筛查肿瘤相似，且在统计学上显著差于筛查发现的癌症。
