Black R D, Middleton H L, Cates G D, Cofer G P, Driehuys B, Happer W, Hedlund L W, Johnson G A, Shattuck M D, Swartz J C
Center for in Vivo Microscopy, Duke University Medical Center, Durham, NC 27710, USA.
Radiology. 1996 Jun;199(3):867-70. doi: 10.1148/radiology.199.3.8638019.
The authors imaged the lungs of live guinea pigs with hyperpolarized (HP) helium-3 as a magnetic resonance (MR) signal source. HP He-3 gas produced through spin exchange with rubidium metal vapor was delivered through an MR-compatible, small-animal ventilator. Two- and three-dimensional lung images acquired with ventilation-gated, radial k-space sampling showed complete ventilation of both lungs. All images were of high quality, demonstrating that HP He-3 allows high-signal-intensity MR imaging in living systems.
作者以超极化（HP）氦-3作为磁共振（MR）信号源，对活体豚鼠的肺部进行成像。通过与铷金属蒸汽进行自旋交换产生的HP氦-3气体，通过一台与MR兼容的小动物呼吸机输送。采用通气门控、径向k空间采样获取的二维和三维肺部图像显示，双肺通气完全。所有图像质量都很高，表明HP氦-3能够在活体系统中实现高信号强度的MR成像。
