Fung-Leung W P, Surh C D, Liljedahl M, Pang J, Leturcq D, Peterson P A, Webb S R, Karlsson L
R. W. Johnson Pharmaceutical Research Institute, San Diego, CA 92121, USA.
Science. 1996 Mar 1;271(5253):1278-81. doi: 10.1126/science.271.5253.1278.
HLA-DM (DM) facilitates peptide loading of major histocompatibility complex class II molecules in human cell lines. Mice lacking functional H2-M, the mouse equivalent of DM, have normal amounts of class II molecules at the cell surface, but most of these are associated with invariant chain-derived CLIP peptides. These mice contain large numbers of CD4+ T cells, which is indicative of positive selection in the thymus. Their CD4+ cells were unresponsive to self H2-M-deficient antigen-presenting cells (APCs) but were hyperreactive to wild-type APCs. H2-M-deficient APCs failed to elicit proliferative responses from wild-type T cells.
HLA-DM（DM）可促进人类细胞系中主要组织相容性复合体II类分子的肽负载。缺乏功能性H2-M（DM的小鼠等同物）的小鼠，其细胞表面II类分子数量正常，但其中大多数与恒定链衍生的CLIP肽相关联。这些小鼠含有大量CD4 + T细胞，这表明在胸腺中发生了阳性选择。它们的CD4 +细胞对自身H2-M缺陷的抗原呈递细胞（APC）无反应，但对野生型APC反应过度。H2-M缺陷的APC未能引发野生型T细胞的增殖反应。
