Søgaard P, Møller B R, Thorsen P, Nissen L R, Pedersen S, Kargo J C, Jensen A M
Klinisk mikrobiologisk afdeling, Arhus Kommunehospital.
Ugeskr Laeger. 1996 Feb 5;158(6):759-63.
The purpose of the investigation was 1) to determine the prevalence of C. trachomatis among young men and women enrolled in military service, 2) to compare enzyme-immunoassay (EIA) of a urethral swab with a sample of first voided morning urine, 3) to determine frequency of earlier venereal diseases (VD) and actual symptoms of urethritis and cervicitis. EIA positive specimens were confirmed by immunofluorescent microscopy. The investigation comprised 831 men and 80 women (17-26 years). The prevalence was 5.7% (95% confidence limits 4.2-7.4%) and 15% (8-25%) for men and women, respectively (p < 0.005, chi 2). The agreement between the results of the urethral swab and the urine sample was low. Sensitivity and positive predictive value for urethral swab was better than for urine. The handling of urine specimens was more laborious and confirmation more difficult. The percentage of actual symptoms among Chlamydia positive men was 6. The frequency of earlier VD was 7.5% and 10% among men and women, respectively. Treatment with tetracycline was effective, which makes control of eradication unnecessary. We conclude that genital chlamydial infection among young asymptomatic people is common and screening would be desirable. We still recommend urethral swabbing as the routine method until simpler and/or more reliable assays for urine specimens are developed.
1）确定应征入伍的青年男女中沙眼衣原体的感染率；2）比较尿道拭子酶免疫测定法（EIA）与首次晨尿样本检测结果；3）确定既往性病（VD）的发病率以及尿道炎和宫颈炎的实际症状。EIA阳性标本通过免疫荧光显微镜检查加以确认。本次调查涵盖831名男性和80名女性（年龄在17至26岁之间）。男性和女性的感染率分别为5.7%（95%置信区间4.2 - 7.4%）和15%（8 - 25%）（p < 0.005，卡方检验）。尿道拭子和尿液样本检测结果之间的一致性较低。尿道拭子的敏感性和阳性预测值优于尿液检测。尿液标本处理更繁琐，确诊也更困难。衣原体阳性男性中实际出现症状的比例为6%。既往性病的发病率在男性和女性中分别为7.5%和10%。四环素治疗有效，因此无需进行根除控制。我们得出结论，年轻无症状人群中的生殖道衣原体感染很常见，进行筛查是可取的。在开发出更简单和/或更可靠的尿液标本检测方法之前，我们仍建议将尿道拭子检查作为常规方法。
