[Epidermodysplasia verruciformis, human Papillomavirus infection, genital epithelial neoplasia and possible immunodeficiency].

Papilloma virus infections are common in patients with immune defect/suppression. We describe a case of regional localised epidermodysplasia verruciformis in combination with genital intraepithelial neoplasia, refractory anaemia, and impaired immunity as demonstrated by lymphopenia with reduced B-cell/T-cell ratio, but normal T-helper/T-suppressor (CD4/CD8) ratio, and neutrophils with reduced spontaneous migration and chemotaxis. The regional localisation of the lesion and the changes in the cell mediated immunity are not classical for epidermodysplasia verruciformis. It is concluded that an increased tendency to papilloma virus infections and/or intraepithelial neoplasia should alert the clinician to the possibility of an immune defect.