Hsu W L, Shueng P W, Jen Y M, Wu C J, Liu H S, Su C C, Hwang J M
Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Am J Clin Oncol. 1996 Jun;19(3):263-7. doi: 10.1097/00000421-199606000-00011.
Between June 1987 and May 1991, 30 patients with Stage IIIB cervical cancers were treated using synchronous radiotherapy, 5-fluorouracil (5-FU), and daily low-dose cisplatin. External radiotherapy (3,600-3,960 cGy) was given to the whole pelvis in 4 weeks. Two courses of intracavitary brachytherapy were given 2 weeks later. Parametrial boost was then given. Continuous infusion of 5-FU 750 mg/m2 was given for 5 days during the first and third week of pelvic irradiation. Cisplatin (6 mg/m2) was given 30 min before every irradiation in the second and fourth week. The complete response rate was 87%. The 3-year local control rate was 77%. The 3-year overall and disease-free survival rate was 66% and 56%, respectively. Distant metastases were the major causes of treatment failure. Toxicities were acceptable. Our preliminary results indicate that this synchronous combination treatment is feasible. Further follow-up is required to determine whether this regimen has a genuine favorable impact on survival and chronic toxicity.
1987年6月至1991年5月期间，30例IIIB期宫颈癌患者接受了同步放疗、5-氟尿嘧啶（5-FU）和每日低剂量顺铂治疗。在4周内对整个盆腔进行体外放疗（3600-3960 cGy）。2周后进行两个疗程的腔内近距离放疗。然后进行宫旁加量放疗。在盆腔照射的第一周和第三周，连续5天输注5-FU 750 mg/m²。在第二周和第四周的每次放疗前30分钟给予顺铂（6 mg/m²）。完全缓解率为87%。3年局部控制率为77%。3年总生存率和无病生存率分别为66%和56%。远处转移是治疗失败的主要原因。毒性反应可以接受。我们的初步结果表明，这种同步联合治疗是可行的。需要进一步随访以确定该方案是否对生存和慢性毒性有真正的有利影响。
