一名非霍奇金淋巴瘤患者的副肿瘤性天疱疮

Paraneoplastic pemphigus in a patient with non-Hodgkin's lymphoma.

作者信息

Plumb R, Doolittle G C

机构信息

Division of Clinical Oncology, University of Kansas Medical Center, Kansas City 66160-7353, USA.

出版信息

Am J Hematol. 1996 May;52(1):58-9. doi: 10.1002/(SICI)1096-8652(199605)52:1<58::AID-AJH10>3.0.CO;2-3.

DOI:10.1002/(SICI)1096-8652(199605)52:1<58::AID-AJH10>3.0.CO;2-3

PMID:8638613

Abstract

Paraneoplastic pemphigus (PNP) is an autoimmune disorder occurring in the setting of an underlying neoplasm in which patients have polymorphous skin and mucous membrane lesions. We describe a patient with non-Hodgkin's lymphoma who developed bullous, ulcerating lesions in an area being treated with radiation therapy. The diagnosis of PNP was confirmed by indirect immunofluorescence of the patient's serum on rat bladder. The disorder was refractory to therapy, and ultimately the patient expired.

摘要

副肿瘤性天疱疮（PNP）是一种发生于潜在肿瘤背景下的自身免疫性疾病，患者会出现多形性皮肤和黏膜损害。我们描述了一名非霍奇金淋巴瘤患者，其在接受放射治疗的部位出现了大疱性、溃疡性损害。通过患者血清对大鼠膀胱进行间接免疫荧光检测，确诊为PNP。该疾病对治疗无效，最终患者死亡。