Calvert G M, Willie K K, Sweeney M H, Fingerhut M A, Halperin W E
Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.
Arch Environ Health. 1996 Mar-Apr;51(2):100-7. doi: 10.1080/00039896.1996.9936001.
2,3,7,8-Tetrachlorodibenzo-p-dioxin alters lipid metabolism in animals; however, evidence for such an effect in humans is conflicting. This conflict was addressed using data from a cross-sectional medical study conducted between 1987 and 1988. The exposed participants had been employed at least 15 y earlier in the manufacture of 2,4,5-trichlorophenol or one of its derivatives at two chemical plants in the United States. A total of 281 workers and 260 unexposed referents participated. Workers had substantial exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin, evidenced by a median serum 2,3,7,8-tetrachlorodibenzo-p-dioxin concentration of 406.6 femtograms/gram of serum (fg/g serum), compared with 36.9 fg/g serum among the referents. A slight association between triglyceride concentration and serum 2,3,7,8-tetrachlorodibenzo-p-dioxin concentration was found (p = .05). Over the range of observed 2,3,7,8-tetrachlorodibenzo-p-dioxin values (i.e., 37-19000 fg/g serum), triglyceride concentration increased only about 0.4 mmol/I. No association was found between an abnormally elevated triglyceride (i.e., > 2.82 mmol/I) concentration and serum 2,3,7,8-tetrachlorodibenzo-p-dioxin concentration. An association was also found between serum 2,3,7,8-tetrachlorodibenzo-p-dioxin concentration and an abnormal high-density lipoprotein concentration (p = .09). in summary, there was evidence of an effect on lipid metabolism in a group of workers with high serum 2,3,7,8-tetrachlorodibenzo-p-dioxin concentrations. The influence of serum 2,3,7,8-tetrachlorodibenzo-p-dioxin on lipid concentrations, however, was small, compared with the influence of other factors.
2,3,7,8-四氯二苯并对二恶英会改变动物的脂质代谢；然而，关于这种影响在人类中的证据存在矛盾。利用1987年至1988年进行的一项横断面医学研究的数据解决了这一矛盾。暴露组参与者至少在15年前受雇于美国两家化工厂，从事2,4,5-三氯苯酚或其衍生物之一的生产工作。共有281名工人和260名未暴露的对照者参与。工人大量接触2,3,7,8-四氯二苯并对二恶英，血清2,3,7,8-四氯二苯并对二恶英浓度中位数为406.6飞克/克血清（fg/g血清）可证明，而对照者中该浓度为36.9 fg/g血清。发现甘油三酯浓度与血清2,3,7,8-四氯二苯并对二恶英浓度之间存在轻微关联（p = 0.05）。在观察到的2,3,7,8-四氯二苯并对二恶英值范围内（即37 - 19000 fg/g血清），甘油三酯浓度仅增加约0.4 mmol/L。未发现甘油三酯异常升高（即> 2.82 mmol/L）浓度与血清2,3,7,8-四氯二苯并对二恶英浓度之间存在关联。还发现血清2,3,7,8-四氯二苯并对二恶英浓度与异常高密度脂蛋白浓度之间存在关联（p = 0.09）。总之，有证据表明血清2,3,7,8-四氯二苯并对二恶英浓度高的一组工人的脂质代谢受到了影响。然而，与其他因素的影响相比，血清2,3,7,8-四氯二苯并对二恶英对脂质浓度的影响较小。
