bcl-2在葡萄膜恶性黑色素瘤中的表达。
Expression of bcl-2 in uveal malignant melanoma.
作者信息
Jay V, Yi Q, Hunter W S, Zielenska M
机构信息
Department of Pathology, Hospital for Sick Children, Toronto, Ontario, Canada.
出版信息
Arch Pathol Lab Med. 1996 May;120(5):497-8.
OBJECTIVE
To evaluate the expression of the bcl-2 proto-oncogene in uveal malignant melanomas.
CASE MATERIAL
We studied 20 uveal malignant melanomas (19 choroidal and 1 ciliary body) by immunohistochemistry with the bcl-2 oncoprotein monoclonal antibody and the cell proliferation marker, MIB-1.
RESULTS
Expression of bcl-2 was found in 100% of cases and was not correlated with the histologic subtype of melanoma or the MIB-1 proliferative index. Normal choroidal melanocytes were negative for bcl-2.
CONCLUSION
Our results suggest that altered expression of bcl-2 is common in uveal melanomas and is not related to histologic grade.
目的
评估bcl-2原癌基因在葡萄膜恶性黑色素瘤中的表达情况。
病例材料
我们采用bcl-2癌蛋白单克隆抗体和细胞增殖标志物MIB-1，通过免疫组织化学方法研究了20例葡萄膜恶性黑色素瘤（19例脉络膜黑色素瘤和1例睫状体黑色素瘤）。
结果
在所有病例中均发现bcl-2表达，且其与黑色素瘤的组织学亚型或MIB-1增殖指数无关。正常脉络膜黑色素细胞bcl-2呈阴性。
结论
我们的结果表明，bcl-2表达改变在葡萄膜黑色素瘤中很常见，且与组织学分级无关。
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