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印记基因的内含子数量少且小吗?

Do imprinted genes have few and small introns?

作者信息

Haig D

机构信息

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

出版信息

Bioessays. 1996 May;18(5):351-3. doi: 10.1002/bies.950180504.

Abstract

A gene is described as imprinted if its pattern of expression depends on whether it passed the previous generation in a male or female germ line. A recent paper reports that imprinted genes have fewer and smaller introns than a control set of genes. The differences are striking but their interpretation is unclear. The loss of introns after a gene becomes imprinted is not sufficient to explain why imprinted genes have fewer introns than average, because related unimprinted genes also have few introns. Similarly, small introns appear to be a property of chromosomal region rather than of imprinting status itself, because neighboring unimprinted genes also have small introns.

摘要

如果一个基因的表达模式取决于它是通过雄性还是雌性生殖系从上一代传递而来,那么这个基因就被称为印记基因。最近一篇论文报道,与一组对照基因相比,印记基因的内含子数量更少且更小。这些差异很显著,但对它们的解释尚不清楚。一个基因成为印记基因后内含子的丢失并不足以解释为什么印记基因的内含子比平均水平少,因为相关的非印记基因也有较少的内含子。同样,小内含子似乎是染色体区域的一个特性,而不是印记状态本身的特性,因为相邻的非印记基因也有小内含子。

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