Emilia G, Messora C, Longo G, Bertesi M
Dipartimento di Scienze Mediche, Oncologiche e Radiologiche, Università di Modena, Italy.
Br J Haematol. 1996 May;93(2):341-4. doi: 10.1046/j.1365-2141.1996.4871026.x.
We report on long-term treatment (13-62 months) with cyclosporin A (CyA) in eight patients with autoimmune haematological disorders, resistant to all usual therapies. Three patients had an autoimmune haemolytic anaemia (AHA); four an idiopathic thrombocytopenic purpura (ITP), and one an Evans syndrome. All patients were responsive: six achieved complete remission and two partial remission. The side-effects were moderate and transient. The majority of surviving patients remain dependent on continued drug administration. The CyA appears to be recommendable as a salvage treatment in life-threatening, resistant autoimmune haematological diseases.
我们报告了对8例自身免疫性血液疾病患者进行环孢素A（CyA）长期治疗（13 - 62个月）的情况，这些患者对所有常规治疗均耐药。3例患有自身免疫性溶血性贫血（AHA）；4例患有特发性血小板减少性紫癜（ITP），1例患有伊文氏综合征。所有患者均有反应：6例实现完全缓解，2例部分缓解。副作用为中度且短暂。大多数存活患者仍依赖持续给药。环孢素A似乎可作为危及生命的、耐药的自身免疫性血液疾病的挽救治疗方法。
