Cowan C E, Federle T W, Larson R J, Feijtel T C
Procter & Gamble Company, Ivorydale Technical Center, Cincinnati, Ohio, USA.
SAR QSAR Environ Res. 1996;5(1):37-49. doi: 10.1080/10629369608031705.
The biodegradability of a substance depends on the structure and physical form of the substance, the time that has been available for acclimation, and the environmental conditions. Importantly, these later factors can be just as important as structure in determining the outcome of a biodegradation test. The development of appropriate QSARs for biodegradation and the ultimate value of the final QSAR depends on understanding these factors. This paper will describe what is known about the effect of test conditions on the results of biodegradation tests. The ability of these tests to reflect real environmental conditions will also be examined. Finally, we will discuss what we believe, in the light of this information, should be the goal of biodegradation QSARs and how these QSARs can be most appropriately used in fate assessments.
一种物质的生物降解性取决于该物质的结构和物理形态、可供驯化的时间以及环境条件。重要的是，在确定生物降解测试结果时，这些后期因素可能与结构同样重要。开发适用于生物降解的定量构效关系（QSARs）以及最终QSAR的最终价值取决于对这些因素的理解。本文将描述关于测试条件对生物降解测试结果影响的已知情况。还将考察这些测试反映实际环境条件的能力。最后，鉴于这些信息，我们将讨论生物降解QSARs的目标应该是什么，以及这些QSARs如何能最适当地用于归宿评估。
