Identification of 3 beta-hydroxy-5 alpha-cholest-6-ene-5-hydroperoxide in human oxidized LDL.
作者信息
Caruso D, Rasetti M F, De Angelis L, Galli G
机构信息
Institute of Pharmacological Sciences, Milan, Italy.
出版信息
Chem Phys Lipids. 1996 Mar 29;79(2):181-6. doi: 10.1016/0009-3084(95)02519-7.
PMID:8640903
Abstract
Oxidized LDL exhibits cytotoxic activity towards endothelial cells, which is thought to be mediated by the products derived also from cholesterol oxidation, mainly involving the B-ring. By LC-PB-EI-MS and EI-MS/MS analysis, we have identified 3 beta-hydroxy-5 alpha-cholest-6-ene-5-hydroperoxide among the cholesterol oxidation products in LDL incubated with micromolar concentrations of copper ions.
摘要
Zotero 插件