Escobedo L G, Zack M M
Office on Smoking and Health, Centers for Disease Control and Prevention, Atlanta, Ga 30333, USA.
Circulation. 1996 Jun 1;93(11):2033-6. doi: 10.1161/01.cir.93.11.2033.
The present study was designed to compare risk factor prevalences in coronary heart disease deaths in persons dying within 1 hour of onset of cardiovascular symptoms (sudden coronary death), those dying without such sudden symptoms (nonsudden coronary death), and those with unknown duration of symptoms before death (other coronary death).
Data from the 1986 National Mortality Followback Survey and the US Bureau of the Census were examined to assess death rates for sudden, nonsudden, and other coronary deaths. Multivariate logistic regression methods were used to calculate the odds ratio (OR), compared with nonsudden and other coronary deaths, for sudden coronary death associated with socioeconomic status variables, the person's location at death, and coronary heart disease risk factors. Mortality rates for all coronary deaths increased with age, were higher for men than women, and increased with decreasing years of schooling. The rate of sudden coronary death was highest for Hispanics. In 1986, an estimated 251,000 sudden coronary deaths (95% CI = 238,000 to 263,000) occurred in the United States. Sudden coronary deaths were less likely than nonsudden coronary deaths to occur at home (OR = 0.5, 95% CI = 0.4 to 0.6), but individuals who died of sudden coronary death were more likely to have been current cigarette smokers (OR = 1.3, 95% CI = 1.0 to 1.8). No other modifiable risk factors for coronary heart disease distinguished sudden coronary deaths from nonsudden coronary deaths.
Contrary to the commonly held view, coronary deaths in the home are more likely to be nonsudden than sudden. Cigarette smoking more likely results in sudden than nonsudden coronary death, perhaps because of nicotine-induced ventricular arrhythmias.
本研究旨在比较心血管症状发作后1小时内死亡者(心源性猝死)、无此类突发症状死亡者(非心源性猝死)以及死亡前症状持续时间不明者(其他冠心病死亡)冠心病死亡的危险因素患病率。
对1986年全国死亡率追踪调查和美国人口普查局的数据进行了分析,以评估心源性猝死、非心源性猝死和其他冠心病死亡的死亡率。采用多变量逻辑回归方法计算与非心源性猝死和其他冠心病死亡相比,心源性猝死与社会经济地位变量、死亡地点和冠心病危险因素相关的比值比(OR)。所有冠心病死亡的死亡率均随年龄增长而增加,男性高于女性,且随受教育年限减少而增加。西班牙裔的心源性猝死率最高。1986年,美国估计发生了25.1万例心源性猝死(95%置信区间=23.8万至26.3万)。心源性猝死在家中发生的可能性低于非心源性猝死(OR=0.5,95%置信区间=0.4至0.6),但死于心源性猝死的个体更可能是当前吸烟者(OR=1.3,95%置信区间=1.0至1.8)。没有其他可改变的冠心病危险因素能区分心源性猝死和非心源性猝死。
与普遍观点相反,在家中发生的冠心病死亡更可能是非心源性猝死而非心源性猝死。吸烟导致心源性猝死的可能性大于非心源性猝死,这可能是由于尼古丁诱发室性心律失常所致。