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Kinetics of in vivo conversion of gamma-[3H]aminobutyric acid to gamma-[3H]hydroxybutyric acid by rat brain.

作者信息

Gold B I, Roth R H

出版信息

J Neurochem. 1977 May;28(5):1069-73. doi: 10.1111/j.1471-4159.1977.tb10670.x.

DOI:10.1111/j.1471-4159.1977.tb10670.x
PMID:864458
Abstract
摘要

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Kinetics of in vivo conversion of gamma-[3H]aminobutyric acid to gamma-[3H]hydroxybutyric acid by rat brain.大鼠脑内γ-[³H]氨基丁酸在体内转化为γ-[³H]羟基丁酸的动力学
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The Drug of Abuse Gamma-Hydroxybutyric Acid Exhibits Tissue-Specific Nonlinear Distribution.滥用药物 γ-羟基丁酸呈现组织特异性非线性分布。
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Alterations in gene expression after gamma-hydroxybutyric acid intake-A pilot study.γ-羟基丁酸摄入后基因表达的改变——一项初步研究
Int J Legal Med. 2017 Sep;131(5):1261-1270. doi: 10.1007/s00414-017-1609-3. Epub 2017 May 22.
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Use of a local sensitivity analysis to inform study design based on a mechanistic toxicokinetic model for γ-hydroxybutyric acid.利用局部敏感性分析为基于 γ-羟基丁酸的机制毒代动力学模型的研究设计提供信息。
AAPS J. 2011 Jun;13(2):240-54. doi: 10.1208/s12248-011-9264-y. Epub 2011 Mar 9.
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Concentration-effect relationships for the drug of abuse gamma-hydroxybutyric acid.药物滥用 γ-羟基丁酸的浓度-效应关系。
J Pharmacol Exp Ther. 2010 Jun;333(3):764-71. doi: 10.1124/jpet.109.165381. Epub 2010 Mar 9.
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Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily.非细胞色素P450醛氧化酶:醛脱氢酶超家族
Expert Opin Drug Metab Toxicol. 2008 Jun;4(6):697-720. doi: 10.1517/17425255.4.6.697.
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gamma-Hydroxybutyrate/sodium oxybate: neurobiology, and impact on sleep and wakefulness.γ-羟基丁酸/羟丁酸钠:神经生物学及其对睡眠和觉醒的影响
CNS Drugs. 2006;20(12):993-1018. doi: 10.2165/00023210-200620120-00004.
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gamma-Hydroxybutyrate uptake by rat brain striatal slices.大鼠脑纹状体切片对γ-羟基丁酸的摄取
Neurochem Res. 1985 Mar;10(3):387-96. doi: 10.1007/BF00964607.
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Metabolism of [U-14C]-4-hydroxybutyric acid to intermediates of the tricarboxylic acid cycle in extracts of rat liver and kidney mitochondria.
Eur J Drug Metab Pharmacokinet. 1989 Jan-Mar;14(1):61-70. doi: 10.1007/BF03190843.
10
Failure of gamma-hydroxybutyrate to alter the function of the GABAA receptor complex in the rat cerebral cortex.γ-羟基丁酸未能改变大鼠大脑皮层中GABAA受体复合物的功能。
Psychopharmacology (Berl). 1991;104(3):351-5. doi: 10.1007/BF02246035.