Hastings-Roberts M M, Zeman F J
J Nutr. 1977 Jun;107(6):973-82. doi: 10.1093/jn/107.6.973.
The effects of feeding, throughout gestation, a diet deficient in protein, of pair-feeding, and of supplementing the deficient diet late in gestation on maternal body weight and weights of the products of conception were investigated in the rat. Protein deprivation resulted in net loss of maternal body weight, smaller and thinner placentas with decreased DNA content and placental labyrinth size, reduced uterine tissue weight, and smaller fetuses with retarded bone development. Pair-feeding caused a less severe reduction in maternal, uterine, placental, and fetal weights. Placentas from pair-fed dams had normal cell numbers with reduced cell size. Diet supplementation late in gestation resulted in increased net and total maternal body weight and uterine, placental, and fetal fetal weights, and an apparent partial recovery in fetal bone development. Placental cell size also increased significantly. The results suggest that placental and uterine development in protein-deficient dams is not the limiting factor in fetal development. Availability of protein may be the primary limiting factor, and energy deficit may play a secondary role.
在大鼠中研究了整个妊娠期饲喂蛋白质缺乏饮食、配对饲喂以及在妊娠后期补充缺乏饮食对母体体重和妊娠产物重量的影响。蛋白质剥夺导致母体体重净损失、胎盘更小更薄，DNA含量和胎盘迷路大小降低，子宫组织重量减轻，胎儿更小且骨骼发育迟缓。配对饲喂导致母体、子宫、胎盘和胎儿体重的降低程度较轻。来自配对饲喂母鼠的胎盘细胞数量正常但细胞大小减小。妊娠后期补充饮食导致母体净体重和总体重以及子宫、胎盘和胎儿体重增加，胎儿骨骼发育明显部分恢复。胎盘细胞大小也显著增加。结果表明，蛋白质缺乏母鼠的胎盘和子宫发育不是胎儿发育的限制因素。蛋白质的可利用性可能是主要限制因素，能量不足可能起次要作用。
