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1
WAF1/CIP1 structural abnormalities do not contribute to cell cycle deregulation in ovarian cancer.WAF1/CIP1结构异常对卵巢癌细胞周期失调无影响。
Br J Cancer. 1996 Jun;73(11):1398-400. doi: 10.1038/bjc.1996.265.
2
Multiple polymorphisms, but no mutations, in the WAF1/CIP1 gene in human brain tumours.人脑肿瘤中WAF1/CIP1基因存在多种多态性，但无突变。
Br J Cancer. 1995 Nov;72(5):1230-3. doi: 10.1038/bjc.1995.491.
3
Evidence of gene deletion of p21 (WAF1/CIP1), a cyclin-dependent protein kinase inhibitor, in thyroid carcinomas.甲状腺癌中细胞周期蛋白依赖性蛋白激酶抑制剂p21（WAF1/CIP1）基因缺失的证据。
Br J Cancer. 1996 Nov;74(9):1336-41. doi: 10.1038/bjc.1996.546.
4
WAF1/Cip1 gene polymorphism and expression in carcinomas of the breast, ovary, and endometrium.WAF1/Cip1基因多态性及其在乳腺癌、卵巢癌和子宫内膜癌中的表达
Am J Pathol. 1997 Jan;150(1):167-75.
5
Low levels of expression of an inhibitor of cyclin-dependent kinases (CIP1/WAF1) in primary breast carcinomas with p53 mutations.在伴有p53突变的原发性乳腺癌中细胞周期蛋白依赖性激酶抑制剂（CIP1/WAF1）表达水平较低。
Clin Cancer Res. 1995 Aug;1(8):907-12.
6
Association between polymorphism in p21(Waf1/Cip1) cyclin-dependent kinase inhibitor gene and human oral cancer.细胞周期蛋白依赖性激酶抑制剂基因p21（Waf1/Cip1）多态性与人类口腔癌的关联。
Clin Cancer Res. 2000 Jun;6(6):2440-7.
7
Polymorphisms and probable lack of mutation in the WAF1-CIP1 gene in colorectal cancer.结直肠癌中WAF1-CIP1基因的多态性及可能不存在的突变
Oncogene. 1995 Feb 2;10(3):599-601.
8
Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells.转化生长因子β1可在卵巢癌细胞中独立于p53途径诱导CIP1/WAF1表达。
Cell Growth Differ. 1994 Dec;5(12):1301-7.
9
Reduced p21(WAF1/CIP1) protein expression is predominantly related to altered p53 in hepatocellular carcinomas.p21（WAF1/CIP1）蛋白表达降低主要与肝细胞癌中p53改变有关。
Br J Cancer. 2000 Jul;83(1):50-5. doi: 10.1054/bjoc.2000.1310.
10
Lack of mutation in the WAF1/CIP1 gene during bovine leukemia virus-induced leukemogenesis.牛白血病病毒诱导白血病发生过程中WAF1/CIP1基因无突变。
Vet Immunol Immunopathol. 1997 Nov;59(3-4):311-22. doi: 10.1016/s0165-2427(97)00081-0.

引用本文的文献

1
p21 in Cancer Research.癌症研究中的p21
Cancers (Basel). 2019 Aug 14;11(8):1178. doi: 10.3390/cancers11081178.
2
P21WAF1/Cip1 gene expression in primary human hepatocellular carcinoma and its relationship with P53 gene mutation.
J Tongji Med Univ. 1999;19(1):1-5. doi: 10.1007/BF02895583.
3
p53 missense but not truncation mutations are associated with low levels of p21(CIP1/WAF1) mRNA expression in primary human sarcomas.在原发性人类肉瘤中，p53错义突变而非截短突变与低水平的p21（CIP1/WAF1）mRNA表达相关。
Br J Cancer. 2001 Jun 15;84(12):1635-9. doi: 10.1054/bjoc.2001.1844.

本文引用的文献

1
Human epithelial ovarian cancer allelotype.人类上皮性卵巢癌等位基因型
Cancer Res. 1993 May 15;53(10 Suppl):2393-8.
2
Evidence of functional RB protein in epithelial ovarian carcinomas despite loss of heterozygosity at the RB locus.尽管RB基因座存在杂合性缺失，但上皮性卵巢癌中仍有功能性RB蛋白的证据。
Cancer Res. 1994 Feb 1;54(3):610-3.
3
Loss of heterozygosity on chromosome 13 is common only in the biologically more aggressive subtypes of ovarian epithelial tumors and is associated with normal retinoblastoma gene expression.13号染色体杂合性缺失仅在生物学行为更具侵袭性的卵巢上皮性肿瘤亚型中常见，且与视网膜母细胞瘤基因正常表达相关。
Cancer Res. 1994 Feb 1;54(3):605-9.
4
p21 is a universal inhibitor of cyclin kinases.p21是细胞周期蛋白激酶的通用抑制剂。
Nature. 1993 Dec 16;366(6456):701-4. doi: 10.1038/366701a0.
5
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.p21 Cdk相互作用蛋白Cip1是G1期细胞周期蛋白依赖性激酶的有效抑制剂。
Cell. 1993 Nov 19;75(4):805-16. doi: 10.1016/0092-8674(93)90499-g.
6
A cell cycle regulator potentially involved in genesis of many tumor types.一种可能参与多种肿瘤类型发生的细胞周期调节因子。
Science. 1994 Apr 15;264(5157):436-40. doi: 10.1126/science.8153634.
7
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.WAF1/CIP1在p53介导的G1期阻滞和凋亡过程中被诱导。
Cancer Res. 1994 Mar 1;54(5):1169-74.
8
Frequent loss of heterozygosity on chromosome 6 in human ovarian carcinoma.人类卵巢癌中6号染色体杂合性的频繁缺失。
Br J Cancer. 1993 Mar;67(3):551-9. doi: 10.1038/bjc.1993.101.
9
A single nucleotide substitution at codon 31 (Ser/Arg) defines a polymorphism in a highly conserved region of the p53-inducible gene WAF1/CIP1.密码子31（丝氨酸/精氨酸）处的单个核苷酸替换定义了p53诱导基因WAF1/CIP1高度保守区域中的一种多态性。
Oncogene. 1994 Oct;9(10):3021-4.
10
Induction of WAF1/CIP1 by a p53-independent pathway.通过一条不依赖p53的途径诱导WAF1/CIP1。
Cancer Res. 1994 Jul 1;54(13):3391-5.

WAF1/CIP1结构异常对卵巢癌细胞周期失调无影响。

WAF1/CIP1 structural abnormalities do not contribute to cell cycle deregulation in ovarian cancer.

作者信息

Wan M, Cofer K F, Dubeau L

机构信息

Department of Pathology, Kenneth Norris Jr. Comprehensive Cancer Center, Los Angeles, CA 90033, USA.

出版信息

Br J Cancer. 1996 Jun;73(11):1398-400. doi: 10.1038/bjc.1996.265.

DOI:10.1038/bjc.1996.265
PMID:8645586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2074480/
Abstract

Mutations in the WAF1/CIP1 gene were not found in 36 ovarian carcinomas, including tumours with loss of heterozygosity at the WAF1/CIP1 locus and/or lacking p53 mutations. In addition, no association was demonstrable between a polymorphism in a conserved region of the WAF1/CIP1 gene and ovarian carcinoma.

摘要

在36例卵巢癌中未发现WAF1/CIP1基因的突变，其中包括在WAF1/CIP1基因座处杂合性缺失和/或缺乏p53突变的肿瘤。此外，WAF1/CIP1基因保守区域的多态性与卵巢癌之间未显示出相关性。