WAF1/CIP1结构异常对卵巢癌细胞周期失调无影响。
WAF1/CIP1 structural abnormalities do not contribute to cell cycle deregulation in ovarian cancer.
作者信息
Wan M, Cofer K F, Dubeau L
机构信息
Department of Pathology, Kenneth Norris Jr. Comprehensive Cancer Center, Los Angeles, CA 90033, USA.
出版信息
Br J Cancer. 1996 Jun;73(11):1398-400. doi: 10.1038/bjc.1996.265.
Abstract
Mutations in the WAF1/CIP1 gene were not found in 36 ovarian carcinomas, including tumours with loss of heterozygosity at the WAF1/CIP1 locus and/or lacking p53 mutations. In addition, no association was demonstrable between a polymorphism in a conserved region of the WAF1/CIP1 gene and ovarian carcinoma.
摘要
在36例卵巢癌中未发现WAF1/CIP1基因的突变，其中包括在WAF1/CIP1基因座处杂合性缺失和/或缺乏p53突变的肿瘤。此外，WAF1/CIP1基因保守区域的多态性与卵巢癌之间未显示出相关性。
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Human epithelial ovarian cancer allelotype.人类上皮性卵巢癌等位基因型
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