Pallet V, Audouin-Chevallier I, Higueret D, Garcin H, Higueret P
Laboratoire de Nutrition, Université Bordeaux I, Talence, France.
J Steroid Biochem Mol Biol. 1996 Feb;57(3-4):161-5. doi: 10.1016/0960-0760(95)00265-0.
Although adrenalectomy was without effect on the expression of retinoic acid (RA) receptors (RARs), administration of the glucocorticoid analog dexamethasone (Dex) to both control and adrenalectomized rats reduced the expression of these receptors in rat liver. This effect can be mainly attributed to the action of Dex on 4-hydroxylation of RA. Dex, by enhancing 4-hydroxylation of RA, reduces its intracellular concentration thereby leading to a decreased expression of RARs, since RARbeta, the main type of RARs in liver, are known to be up-regulated by RA.
虽然肾上腺切除术对维甲酸（RA）受体（RARs）的表达没有影响，但给对照大鼠和肾上腺切除大鼠注射糖皮质激素类似物地塞米松（Dex）会降低大鼠肝脏中这些受体的表达。这种效应主要可归因于Dex对RA 4-羟基化的作用。Dex通过增强RA的4-羟基化，降低其细胞内浓度，从而导致RARs表达降低，因为肝脏中主要的RARs类型RARβ已知受RA上调。
