依那普利在新生儿高血压中的应用。
Use of enalapril in neonatal hypertension.
作者信息
Schilder J L, Van den Anker J N
机构信息
Department of Pediatrics, Erasmus University, Rotterdam, The Netherlands.
出版信息
Acta Paediatr. 1995 Dec;84(12):1426-8. doi: 10.1111/j.1651-2227.1995.tb13581.x.
Treatment of hypertension with enalapril in a preterm infant is described. Enalapril is a new converting enzyme blocker with a longer plasma half-life and less side effects than captopril. Oral administration of enalapril 0.1 mg/kg caused severe hypotension and renal failure in a preterm infant. We recommend an oral starting dose of 0.01 mg/kg in preterm infants and extremely close monitoring of infants receiving the first dose of enalapril.
本文描述了用依那普利治疗一名早产儿高血压的情况。依那普利是一种新型的转换酶阻滞剂，其血浆半衰期比卡托普利长，副作用比卡托普利少。给一名早产儿口服0.1毫克/千克的依那普利导致了严重的低血压和肾衰竭。我们建议早产儿口服依那普利的起始剂量为0.01毫克/千克，并对接受首剂依那普利的婴儿进行极其密切的监测。
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