Schechter P J, Tranier Y, Jung M J, Sjoerdsma A
J Pharmacol Exp Ther. 1977 Jun;201(3):606-12.
gamma-Acetylenic gamma-aminobutyric acid (gamma-acetylenic GABA) produces several-fold sustained elevations of brain GABA concentrations when administered intraperitoneally to mice. It protects mice against seizures induced by audiogenic stimuli, electroshock, thiosemicarbazide, isoniazid and strychnine. The duration and degree of audiogenic seizure protection appears to correlate with elevations in whole brain GABA levels. gamma-Acetylenic GABA does not protect against seizures induced by pentylenetetrazol or picrotoxin even at doses that increase brain GABA concentrations approximately 6-fold. This differential antiseizure activity suggests that the GABA system may play a role in some, but not all experimentally produced seizures.
γ-乙炔基γ-氨基丁酸（γ-乙炔基GABA）腹腔注射给小鼠时，可使脑内GABA浓度持续升高数倍。它能保护小鼠免受听源性刺激、电休克、氨基硫脲、异烟肼和士的宁诱发的癫痫发作。听源性癫痫发作保护的持续时间和程度似乎与全脑GABA水平的升高相关。即使在能使脑内GABA浓度增加约6倍的剂量下，γ-乙炔基GABA也不能保护小鼠免受戊四氮或印防己毒素诱发的癫痫发作。这种不同的抗癫痫活性表明，GABA系统可能在某些但并非所有实验性癫痫发作中起作用。
