某些抗惊厥γ-氨基丁酸转氨酶抑制剂对兔离体心脏抗纤颤活性的研究：与苯妥英和美西律的比较。
Investigation of the antifibrillatory activity of some anticonvulsant gamma-aminobutyric acid-transaminase inhibitors in the rabbit isolated heart: comparison with phenytoin and mexiletine.
作者信息
Almotrefi A A, Baker J B
出版信息
Br J Pharmacol. 1980;71(2):635-9. doi: 10.1111/j.1476-5381.1980.tb10984.x.
Abstract
1 The electrical stimulation and ventricular fibrillation thresholds were measured in the Langendorff-perfused rabbit heart by application of rectangular impulses of 3 ms duration and increasing current at frequencies of 4 and 20 Hz respectively. 2 Perfusion with either phenytoin or mexiletine produced significant dose-dependent increases in both thresholds. 3 Perfusion with four anticonvulsant inhibitors of gamma-aminobutyric acid (GABA)-transaminase, aminooxyacetic acid, gamma-acetylenic GABA, gamma-vinyl GABA and sodium valproate, up to a concentration of 20 microgram/ml, had no significant effect on either threshold. 4 The results suggest that these compounds, unlike phenytoin and mexiletine, are devoid of antifibrillatory activity.
摘要
- 通过分别施加持续时间为3毫秒的矩形脉冲，并以4赫兹和20赫兹的频率增加电流，在Langendorff灌注兔心脏中测量电刺激和室颤阈值。2. 用苯妥英或美西律灌注可使两种阈值都产生显著的剂量依赖性增加。3. 用四种γ-氨基丁酸（GABA）-转氨酶的抗惊厥抑制剂，即氨氧基乙酸、γ-乙炔基GABA、γ-乙烯基GABA和丙戊酸钠，以高达20微克/毫升的浓度灌注，对两种阈值均无显著影响。4. 结果表明，与苯妥英和美西律不同，这些化合物没有抗纤颤活性。
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本文引用的文献
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Effects of diphenylhydantoin sodium (dilantin sodium) and phenobarbital sodium upon ectopic ventricular tachycardia in acute myocardial infarction.苯妥英钠（大仑丁钠）和苯巴比妥钠对急性心肌梗死时异位室性心动过速的影响。
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